Angiosarcoma suprarrenal primario. Reporte de caso

Palabras clave

Primary adrenal epithelioid angiosarcoma
poor prognosis Angiosarcoma epitelioide suprarrenal primario
mal pronóstico

Cómo citar

Castellanos Donoso, P., Sánchez Pérez , M. P., Cárdenas Aguirre , C., Ortiz Barbosa , A., Galván Gómez , C. M., Murube Jimenez , A., & Rey Nodar , S. (2023). Angiosarcoma suprarrenal primario. Reporte de caso. Archivos De Patologia, 3(3), 96–103.


Primary adrenal angiosarcoma is a rare vascular malignancy with fewer than fifty cases reported in the literature, with a preference for middle-aged men and a poor prognosis with a median survival of around eighteen months and a five-year overall survival of 30 %. A case of a 61-year-old male patient who consulted for pain in the left renal fossa radiating to the ipsilateral flank and constitutional syndrome is reported. Diagnostic imaging tests show a large solid left adrenal mass with no signs of local tumor extension or in other organs; Laboratory studies confirm autoproduction of cortisol and association with probable paraneoplastic consumptive coagulopathy. Open left adrenalectomy was performed with an anatomopathological diagnosis of primary epithelioid angiosarcoma of the adrenal gland and liver metastases. During the immediate postoperative period, hematoma of the surgical site was evidenced, which was treated conservatively with favorable evolution. Subsequently, adjuvant chemotherapy treatment with paclitaxel was administered, presenting metastatic progression in diagnostic imaging tests five weeks after surgery. Exitus letalis, presented three months after surgery.


Ladenheim A, Tian M, Afify A, Campbell M, Kamangar E. Primary Angiosarcoma of the Adrenal Gland: Report of 2 Cases and Review of the Literature. Int J Surg Pathol. 2022 Feb;30(1): 76-85.

Hart J, Mandavilli S. Epithelioid angiosarcoma: a brief diagnostic review and differential diagnosis. Arch Pathol Lab Med. 2011 Feb;135(2): 268-72. PMID: 21284449.

Imran S, Allen A, Saeed DM, Garzon S, Xie K. Adrenal angiosarcoma with metastasis: Imaging and histopathology of a rare adrenal cancer. Radiol Case Rep. 2020 Feb 22;15(5): 460-66.

Yang F, Yang Y, Yu J, Zheng J, Zhu Y, Shao D, Chen D, Wang S. Primary epithelioid angiosarcoma of the adrenal gland: aggressive histological features and clinical behavior. Int J Clin Exp Pathol. 2018 May 1;11(5):2721-27.

Cornejo KM, Hutchinson L, Cyr MS, Nose V, McLaughlin PJ, Iafrate AJ, Sadow PM. MYC analysis by fluorescent in situ hybridization and immunohistochemistry in primary adrenal angiosarcoma (PAA): a series of four cases. Endocr Pathol. 2015;26: 334-41.

Schreiner AM, Hoda RS. Primary adrenal epithelioid angiosarcoma showing rhabdoid morphology on air-dried smears. Diagn Cytopathol. 2012;40(Suppl 2): E162-64.

Kareti LR, Katlein S, Siew S, Blauvelt A. Angiosarcoma of the adrenal gland. Arch Pathol Lab Med. 1988;112: 1163-65.

Liu SS, Bellamkonda V, Phung TL. Angiosarcoma. Accessed February 11th, 2023.

Mayo-Smith W, Song J, Boland G et al. Management of Incidental Adrenal Masses: A White Paper of the ACR Incidental Findings Committee. J Am Coll Radiol. 2017;14(8): 1038-44. j.jacr.2017.05.001

Johnson P, Horton K, Fishman E. Adrenal Mass Imaging with Multidetector CT: Pathologic Conditions, Pearls, and Pitfalls. Radiographics. 2009;29(5): 1333-51.

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